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PEA safeguards towards bacterial an infection by using innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA at a dose of 0.1 mg/kg body bodyweight extended survival charge and reduced neuro-inflammation within an aged murine bacterial meningitis design, in the absence of antibiotics [42].The latter is of Specific inte
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2016a). This smaller improve was proportionate for the lesser peak of PEA levels detected in human volunteers in comparison with beagle dogs. This big difference, subsequently, is usually a result of the decreased whole quantity of PEA acutely administered to human volunteers (about ∼five vs. 30 mg·kg−1 in pet dogs) and to the fact that this